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Chemistry (kind of) help - March 7th 2014, 10:48 PM

Hi guys,

So I haven't done chemistry in a while and I've forgotten some of the basic calculations. I need to know these calculations for my Pharmacology coursework so I was wondering if anybody could help.

Basically we did an experiment on a virtual rat which had a mass of 1kg/L.

We then injected some drugs and stuff and measured the response. I need to convert the drug concentrations into molar instead of mg/kg and micrograms/kg.

Could someone explain how to do this?

One of the drug concentrations is 10micrograms/kg so how would I convert that to molar? The molecular weight of this drug is 211.

One of the other drugs is in mg/kg so do I need to divide that by 1000 at any point to get them all in the same scale?

I'm just really confused so hopefully somebody can help since I already bothered the lecturer once this week about this coursework
   
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Re: Chemistry (kind of) help - March 8th 2014, 12:09 PM

Okay, let's see how much chemistry I actually remember, without hitting my books.

Molecular weight is 211, so 1 mole of the drug has a mass of 211g.

Concentration is 10 microgram/kg.
10 micrograms / 211g is the number of moles.
10 x 10^-6 g / 211 g = 4.74 x 10^-8 moles (rounded)

So there are 4.74 x 10^-8 moles/kg

If the density of the solution is 1L/kg, then it's a concentration of 4.74 x 10^-8 M. However, the density of the solution irl is likely to be not exactly 1L/kg.

With the other drug, you just need to convert the concentration to g (so it would be, for example, 10 x 10^-3 g).

Does that make any sense?


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