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  (#1 (permalink)) Old
Blackwing Offline
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Man appears free of HIV after stem cell transplant - February 26th 2010, 04:09 AM

A 42-year-old HIV patient with leukemia appears to have no detectable HIV in his blood and no symptoms after a stem cell transplant from a donor carrying a gene mutation that confers natural resistance to the virus that causes AIDS, according to a report published Wednesday in the New England Journal of Medicine.

"The patient is fine," said Dr. Gero Hutter of Charite Universitatsmedizin Berlin in Germany. "Today, two years after his transplantation, he is still without any signs of HIV disease and without antiretroviral medication."
The case was first reported in November, and the new report is the first official publication of the case in a medical journal. Hutter and a team of medical professionals performed the stem cell transplant on the patient, an American living in Germany, to treat the man's leukemia, not the HIV itself.
However, the team deliberately chose a compatible donor who has a naturally occurring gene mutation that confers resistance to HIV. The mutation cripples a receptor known as CCR5, which is normally found on the surface of T cells, the type of immune system cells attacked by HIV.
The mutation is known as CCR5 delta32 and is found in 1 percent to 3 percent of white populations of European descent.
HIV uses the CCR5 as a co-receptor (in addition to CD4 receptors) to latch on to and ultimately destroy immune system cells. Since the virus can't gain a foothold on cells that lack CCR5, people who have the mutation have natural protection. (There are other, less common HIV strains that use different co-receptors.)
People who inherit one copy of CCR5 delta32 take longer to get sick or develop AIDS if infected with HIV. People with two copies (one from each parent) may not become infected at all. The stem cell donor had two copies.



http://www.cnn.com/2009/HEALTH/02/11...ref=rss_latest


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  (#2 (permalink)) Old
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Re: Man appears free of HIV after stem cell transplant - February 26th 2010, 05:53 PM

Wow this is amazing.




   
  (#3 (permalink)) Old
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Re: Man appears free of HIV after stem cell transplant - February 26th 2010, 06:44 PM

Woohoo! Now I don't have to use a condom anymore!

...


I'm kidding, haha. Still awesome though.


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  (#4 (permalink)) Old
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Re: Man appears free of HIV after stem cell transplant - February 26th 2010, 07:47 PM

Quote:
Originally Posted by TigerTank77 View Post
Woohoo! Now I don't have to use a condom anymore!

...


I'm kidding, haha. Still awesome though.
Hehe this made me giggle

This is a great thing to hear though. What a huge step forward!


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  (#5 (permalink)) Old
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Re: Man appears free of HIV after stem cell transplant - February 27th 2010, 12:28 AM

Awesome! This really is amazing science


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Re: Man appears free of HIV after stem cell transplant - February 27th 2010, 09:44 AM

Remember all the fuss made about stem cell research some years back? I admit, this makes me feel just a little smug. And very, very happy! Even a glimmer of hope that we might one day beat AIDS is an incredible achievement.


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Re: Man appears free of HIV after stem cell transplant - February 27th 2010, 11:03 AM

This made me smile



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  (#8 (permalink)) Old
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Re: Man appears free of HIV after stem cell transplant - February 27th 2010, 02:07 PM

This Gives Me Hope that we will find a cure for HIV and AIDS. This is such an interesting story.


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  (#9 (permalink)) Old
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Re: Man appears free of HIV after stem cell transplant - February 27th 2010, 02:28 PM

That's amazing I'm happy for him


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  (#10 (permalink)) Old
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Re: Man appears free of HIV after stem cell transplant - February 28th 2010, 09:55 AM

Thats amazing. This is so interesting.


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  (#11 (permalink)) Old
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Re: Man appears free of HIV after stem cell transplant - February 28th 2010, 11:33 AM

Quote:
Originally Posted by Xujhan View Post
Remember all the fuss made about stem cell research some years back? I admit, this makes me feel just a little smug.
I totally agree here .

And yay, we're finally starting to beat HIV..




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Re: Man appears free of HIV after stem cell transplant - February 28th 2010, 02:18 PM

Ah I love Stem Cells, they are so fascinating and just amazing

It is a shame his leukemia relapsed though, since that was what they were originally trying to cure...

Quote:
However, following the transplant, signs of leukemia and HIV were absent.

"There is no really conclusive explanation why we didn't observe any rebound of HIV," Hutter said. "This finding is very surprising."

Hutter noted that one year ago, the patient had a relapse of leukemia and a second transplant from the same donor. The patient experienced complications from the procedure, including temporary liver problems and kidney failure.
   
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Re: Man appears free of HIV after stem cell transplant - February 28th 2010, 03:49 PM

Quote:
Originally Posted by Razzmatazz Rach View Post
Ah I love Stem Cells, they are so fascinating and just amazing

It is a shame his leukemia relapsed though, since that was what they were originally trying to cure...

agreed. i've had a stem cell transplant, from my own stem cells that were previously harvested.

but yeah, this is amazing.


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Re: Man appears free of HIV after stem cell transplant - February 28th 2010, 03:53 PM

Excellent. Now try explaining to me again why stem cell research is so horrible.


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